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What Is the Symptom of Leg Pain? Although leg pain is a common sign of musculoskeletal disease, it can also be caused by more severe vascular or neurological disorders. Pain can be sudden or gradually limited or may affect the entire leg. Continuous or intermittent. The patient may feel numb, hot, sharp, painful or stinging. Leg pain can affect exercise and limit weight. Severe pain in the leg after a limb fracture may be a compartment syndrome. Sudden severe lumbar and leg pain in patients with vascular insufficiency may indicate severe deterioration, leading to arterial grafting or amputation (see prominent...